https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Extraction and encapsulation of bioactive compounds of bitter melon https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22361 Wed 11 Apr 2018 15:08:31 AEST ]]> Gac oil extraction and encapsulation by spray drying https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22008 Wed 11 Apr 2018 11:50:13 AEST ]]> Erlotinib loaded chitosan nanoparticles: formulation, physicochemical characterization and cytotoxic potential https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37112 10 million patients with new cases diagnosed every year. The objective of this study was to prepare and evaluate erlotinib loaded chitosan nanoparticles for their anticancer potential. Also, to study the effect of various formulation variables on prepared nanoparticles using box-behnken design. Erlotinib loaded chitosan nanoparticles were prepared by ionic gelation method using the spray drying technique. It was found that batch SNP-9 has a maximum loading capacity (74.45 ± 0.34%) and entrapment efficiency (43 ± 0.57%) with a particle size 170.2 nm. Analysis of variance (ANOVA) was applied on the particle size, entrapment efficiency and % cumulative drug release to study the fitting and the significance of the model. The batch SNP-9 showed 89.46% and 40.12% drug release after 24 h in 0.1 N HCl and Phosphate Buffer (pH 6.8), respectively. The IC⁵⁰ value of SNP-9 evaluated on A549 Lung cancer cells was found to be 4.41 μM. The optimized formulation was found stable after the six-month study as no considerable transformation was detected. The optimized formulation released erlotinib slowly in comparison to the marketed tablet formulation. Erlotinib loaded chitosan nanoparticles were prepared successfully using spray drying technique with suitable particle size, entrapment efficiency, drug release. The synthesized and optimized nanoparticles were found to possess activity against cancer cells when evaluated in-vitro.]]> Thu 09 Dec 2021 11:02:22 AEDT ]]> Encapsulation of phenolic-rich extract from banana (Musa cavendish) peel https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46816 Thu 01 Dec 2022 09:46:26 AEDT ]]> Effects of spray drying conditions on the physicochemical and antioxidant properties of the Gac (Momordica cochinchinensis) fruit aril powder https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10149 Sat 24 Mar 2018 10:31:23 AEDT ]]> Optimized aqueous extraction of saponins from bitter melon for production of a saponin-enriched bitter melon powder https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20934 Sat 24 Mar 2018 08:06:05 AEDT ]]> Microencapsulation of gac oil by spray drying: optimization of wall material concentration and oil load using response surface methodology https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21068 Sat 24 Mar 2018 07:59:25 AEDT ]]> Microencapsulation of gac oil: optimisation of spray drying conditions using response surface methodology https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21067 Sat 24 Mar 2018 07:59:25 AEDT ]]> Preparation of decaffeinated and high caffeine powders from green tea https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19891 Sat 24 Mar 2018 07:57:09 AEDT ]]> Production of caffeinated and decaffeinated green tea catechin powders from underutilised old tea leaves https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21231 Sat 24 Mar 2018 07:53:04 AEDT ]]> A storage study of encapsulated gac (Momordica cochinchinensis) oil powder and its fortification into foods https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24764 Sat 24 Mar 2018 07:14:08 AEDT ]]> Gac aril processing technology https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53759 Mon 15 Jan 2024 09:48:39 AEDT ]]>